プログラム(口頭発表の部)

第1日　9月27日(火)

午前

9:00-9:50

座長：塚本佐知子 (熊本大院薬)
Chair: Tsukamoto, S. (Graduate School of Pharmaceutical Sciences, Kumamoto University)

1

• 膜タンパク質挿入に関わる新規糖脂質MPIaseの機能と構造
  • (サントリー生科財団^a、岩手大寒冷バイオ^b、盛岡大栄養科学^c)
    ○前田将秀^a、西山賢一^b、永瀬良平^a、岩下　孝^a、小村　啓^a、徳田　元^c、楠本正一^a、島本啓子^a
• Function and Structure of a Novel Glycolipid Characterized as Membrane Protein Integrase
  • Maeda, M.^a, Nishiyama, K.^b, Nagase, R.^a, Iwashita, T.^a, Komura, H.^a, Tokuda, H.^c, Kusumoto, S.^a,
    Shimamoto, K.^a
    (^aBioorganic Research Institute, Suntory Foundation for Life Sciences, ^bCryobiofrontier Research Center, Iwate University, ^cFaculty of Nutritional Sciences, The University of Morioka)

2

• ニュージーランドで発生した赤潮渦鞭毛藻が産生する巨大ポリ環状エーテル化合物の構造決定
  • (東大院理^a、コースロン研^b)
    ○浜本友佳^a、佐竹真幸^a、橘　和夫^a、Holland, Patrick^b、Beuzenberg, Vernonica^b、Feng, Shi^b
• Structural Study on New Red Tide Toxins Collected in New Zealand
  • Hamamoto, Y.^a, Satake, M.^a, Tachibana, K.^a, Holland, P.^b, Beuzenberg, V.^b, Feng, S.^b
    (^aDepartment of Chemistry, The University of Tokyo, ^bLaboratory Service Division, Cawthron Institute)

9:50-11:05

座長：繁森英幸 (筑波大院生命環境)
Chair: Shigemori, H. (Graduate School of Life and Environmental Sciences, University of Tsukuba)

3

• 渦鞭毛藻 Amphidinium sp. 由来新規ポリオール化合物 amdigenol A の構造
  • (岐阜大生命セ^a、岐阜大工^b、神奈川大理^c)
    ○犬塚俊康^a、山本　裕^b、山田　薫^c、上村大輔^c
• Amdigenol A, a Novel Polyol Compound from the Dinoflagellate Amphidinium sp.
  • Inuzuka, T.^a, Yamamoto, Y.^b, Yamada, K.^c, Uemura, D.^c
    (^aLife Science Research Center, Gifu University, ^bFaculty of Engineering, Gifu University, ^cFaculty of Science, Kanagawa University)

4

• 海洋シアノバクテリア由来の新規マクロリドLeptolyngbyalide類の構造と生物活性
  • (慶大理工^a、琉球大教育^b、筑波大院数理物質^c、理研^d)
    ○森田真布^a、大野　修^a、照屋俊明^b、北　将樹^c、木越英夫^c、北村和大^a、平田邦生^d、末永聖武^a
• Structures and Bioactivities of Novel Macrolides Leptolyngbyalides from Marine Cyanobacteria
  • Morita, M.^a, Ohno, O.^a, Teruya, T.^b, Kita, M.^c, Kigoshi, H.^c, Kitamura, K.^a, Hirata, K.^d, Suenaga, K.^a
    (^aFaculty of Science and Technology, Keio University, ^bFaculty of Education, University of the Ryukyus, ^cGraduate School of Pure and Applied Sciences, University of Tsukuba, ^dHarima Institute, RIKEN)

5

• エピジェネティック制御に基づく新規二次代謝物の創出
  • (東北大院薬^a、東北薬大^b、高雄医大天然所^c)
    ○浅井禎吾^a、山本崇史^a、Chung, Yu-Ming^a,c、羅　丹^a、森田峻太郎^a、白田直樹^a、山下幸和^b、大島吉輝^a
• Secondary Metabolite Production from Silent Gene Clusters by Chemical Epigenetics
  • Asai, T.^a, Yamamoto, T.^a, Chung, Y-M.^a,c, Luo, D.^a, Morita, S.^a, Shirata, N.^a, Yamashita, K.^b, Oshima, Y.^a
    (^aGraduate School of Pharmaceutical Sciences, Tohoku University, ^bFaculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, ^cGraduate Institute of Natural products, College of Pharmacy, Kaohsiung Medical University)

11:10-12:10

ショートプレゼンテーション
Short Presentation
座長：臼杵克之助 (阪市大院理)
Chair: Usuki, Y. (Graduate School of Science, Osaka City University)

午後

12:10-14:50

ポスター示説
Poster Presentation

14:50-15:40

座長：山下まり (東北大院農)
Chair: Yotsu-Yamashita, M. (Graduate School of Agricultural Science, Tohoku University)

6

• Alstonia pneumatophora および A. angustiloba 由来の新規多環性インドールアルカロイドの構造研究
  • (星薬大^a、Sains Malaysia 大 ^b)
    ○小山晃一郎^a、平澤祐介^a、金田利夫^a、Nugroho, Alfarius^a、細谷孝博^a、在間一将^a、Hoe, Teh^b、Chan, Lam^b、森田博史^a
• Novel Polycyclic Indole Alkaloids from Alstonia pneumatophora and A. angustiloba
  • Koyama, K.^a, Hirasawa, Y.^a, Kaneda, T.^a, Nugroho, A.^a, Hosoya, T.^a, Zaima, K.^a, Hoe, T.^b, Chan, L.^b, Morita, H.^a
    (^aPharmacognosy, Hoshi University, ^bFaculty of Pharmacy, University Sains Malaysia)

7

• 繊毛虫Blepharisma japonicumの接合誘導物質blepharmoneのN-末端と糖鎖の構造決定
  • (阪市大院理^a、奈良女大理^b、京大生存圏研^c)
    山岸由和^a、臼杵克之助^a、○飯尾英夫^a、春本晃江^b、吉岡康一^c、渡邊隆司^c
• N-Terminal and Glycan of Blepharmone, a Conjugation-inducing Pheromone of Blepharisma japonicum
  • Yamagishi, Y.^a, Usuki, Y.^a, Iio, H.^a, Harumoto, T.^b, Yoshioka, K.^c, Watanabe, T.^c
    (^aGraduate School of Science, Osaka City University, ^bBiological Sciences, Nara Women's University, ^cResearch Institute for SustainableHumanosphere, Kyoto University)

15:40-16:30

座長：島本啓子 (サントリー生科財団)
Chair: Shimamoto, K. (Bioorganic Research Institute, Suntory Foundation for Life Sciences)

8

• 疫病菌交配ホルモンα2
  • (名大院生命農^a、東農大応生科^b、浙江大薬^c)
    ○小鹿　一^a、Molli, Shylaja D.^a、金沢春海^a、矢島　新^b、戸田　皓^b、額田恭郎^b、毛　海萌^a、村田　涼^a、浅野友世^a、戚　建華^c、坂神洋次^a
• Phytophthora Mating Hormone α2
  • Ojika, M.^a, Molli, S. D.^a, Kanazawa, H.^a, Yajima, A.^b, Toda, K.^b, Nukada, T.^b, Mao, H.^a, Murata, R.^a, Asano, T.^a, Qi, J.^c, Sakagami, Y.^a
    (^aGraduate School of Bioagricultural Sciences, Nagoya University, ^bFaculty of Applied Bio-Science, Tokyo University of Agriculture, ^cCollege of Pharmaceutical Sciences, Zhejiang University)

9

• 固体NMRによるPradimicin Aのマンノース認識機構解析
  • (理研基幹研^a、京大院理^b、富山県大生工^c、JST ERATO^d)
    ○中川　優^a、増田裕一^b、山田啓太^b、土井崇嗣^b、竹腰清乃理^b、五十嵐康弘^c、伊藤幸成^a,d
• Solid-state NMR Analysis of Mannose Recognition by Pradimicin A
  • Nakagawa, Y.^a, Masuda, Y.^b, Yamada, K.^b, Doi, T.^b, Takegoshi, K.^b, Igarashi, Y.^c, Ito, Y.^a,d
    (^aSynthetic Cellular Chemistry Laboratory, RIKEN Advanced Science Institute, ^bGraduate School of Science, Kyoto University, ^cBiotechnology Research Center, Toyama Prefectural University, ^dExploratory Research For Advanced Technology, Japan Science And Technology Agency)

16:30-17:20

座長：大神田淳子 (阪大産研)
Chair: Ohkanda, J. (The Institute of Scientific and Industrial Research, Osaka University)

10

• 海洋天然物オーリライドの標的タンパク質決定
  • (京大iCeMS^a、慶大理工^b、筑波大数理^c)
    ○佐藤慎一^a、村田亜沙子^a、折原　翼^a、白川貴詩^a、末永聖武^b、木越英夫^c、上杉志成^a
• Isolating and Identifying Protein Targets of Marine Natural Product Aurilide
  • Sato, S.^a, Murata, A.^a, Orihara, T.^a, Shirakawa, T.^a, Suenaga, K.^b, Kigoshi, H.^c, Uesugi, M.^a
    (^aInstitute for Integrated Cell-Material Sciences, Kyoto University, ^bDepartment of Chemistry, Keio University, ^cDepartment of Chemistry, University of Tsukuba)

11

• 有機合成が先導する海洋光合成を担う多官能性カロテノイドの機能解明
  • (関西学院大理工^a、サントリー生科財団^b、阪市大複合先端^c)
    ○梶川敬之^a、奥村　聡^a、花ノ木祥平^a、矢野亘記^a、岩下　孝^b、小澄大輔^c、堀部智子^c、橋本秀樹^c、勝村成雄^a
• Energy Transfer Mechanism of Polyfunctionalized Carotenoids in Marine Photosynthesis based on Organic Synthesis
  • Kajikawa, T.^a, Okumura, S.^a, Hananoki, S.^a, Yano, K.^a, Iwashita, T.^b, Kosumi, D.^c, Horibe, T.^c, Hashimoto, H.^c, Katsumura, S.^a
    (^aDepartment of Science and Technology, Kwansei Gakuin University, ^bBioorganic Research Institute, Suntory Foundation for Life Sciences, ^cOCU Advanced Research Institute For Natural Science and Technology, Osaka City University)

17:20-18:10

座長：藤本ゆかり (阪大院理)
Chair: Fujimoto, Y. (Graduate School of Science, Osaka University)

12

• カフェオイルキナ酸のアミロイドβ凝集阻害活性及び分子機構
  • (筑波大院生命環境^a、京大院生命科学^b、京大院農学^c)
    ○宮前友策^a,b、栗栖真奈美^a、村上一馬^c、入江一浩^c、Han, Junkyu^a、礒田博子^a、繁森英幸^a
• Caffeoylquinic Acids Inhibit Amyloid β Aggregation and Cellular Toxicity
  • Miyamae, Y.^a,b, Kurisu, M.^a, Murakami, K.^c, Irie, K.^c, Han, J.^a, Isoda, H.^a, Shigemori, H.^a
    (^aGraduate School of Life and Environmental Sciences, University of Tsukuba, ^bGraduate School of Biostudies, Kyoto University, ^cGraduate School of Agriculture, Kyoto University)

13

• 分子プローブを用いた抗腫瘍性物質アプリロニンA の標的分子および作用機序に関する研究
  • (筑波大院数理物質^a、筑波大院人間総合^b)
    ○北　将樹^a、平山裕一郎^a、米田耕三^a、杉山美幸^a、齊藤有希^a、三輪佳宏^b、木越英夫^a
• Study on the Target Molecules and Mode of Actions of an Antitumor Macrolide Aplyronine A by using Its Chemical Probes
  • Kita, M.^a, Hirayama, Y.^a, Yoneda, K.^a, Sugiyama, M.^a, Saito, Y.^a, Miwa, Y.^b, Kigoshi, H.^a
    (^aGraduate School of Pure and Applied Sciences, University of Tsukuba, ^bGraduate School of Comprehensive Human Sciences, University of Tsukuba)

18:10-19:00

座長：入江一浩 (京大院農学)
Chair: Irie, K. (Graduate School of Agriculture, Kyoto University)

14

• オーキシン受容体TIR1に特異的なアンタゴニストとその作用機構
  • (岡山理大^a、ワシントン大薬^b、Leeds大^c)
    ○林　謙一郎^a、広瀬正和^a、Tan, Xu^b、Zheng, Ning^b、Kepinski, Stefan^c、野崎　浩^a
• Auxin Antagonsit Specifc to TIR1 Auxin Receptor
  • Hayashi, K.^a, Hirose, M.^a, Tan, X.^b, Zheng, N.^b, Kepinski, S.^c, Nozaki, H.^a
    (^aDepartment of Biochemistry, Okayama University of Science, ^bDepartment of Pharmacology, University of Washington, ^cCentre for Plant Sciences, University of Leeds)

15

• 抗シガトキシン抗体を利用した太平洋型シガトキシンの微量検出法の開発
  • (阪府大院理^a、東北大院理^b)
    ○円谷　健^a、山下修治^b、竹内勝俊^b、石原祐樹^b、平間正博^b、藤井郁雄^a
• Generation of Anti-ciguatoxin Antibodies for Sandwich ELISA Detection of Pacific Ciguatoxins
  • Tsumuraya, T.^a, Yamashita, S.^b, Takeuchi, K.^b, Ishihara, Y.^b, Hirama, M.^b, Fujii, I.^a
    (^aGraduate School of Science, Osaka Prefecture University, ^bGraduate School of Science, Tohoku University)

第2日　9月28日(水)

午前

9:00-9:50

座長：工藤史貴 (東工大院理工)
Chair: Kudo, F. (Graduate School of Science and Engineering, Tokyo Institute of Technology)

16

• 植物ポリケタイド合成酵素の合理的な酵素触媒機能の拡張による非天然型新規生物活性物質の創出
  • (東大院薬^a、JST CREST^b)
    ○森田洋行^a,b、森　貴裕^a,b、山下　誠^a、脇本敏幸^a,b、阿部郁朗^a,b
• Enzymatic Synthesis of Unnatural Novel Biologically Active Compounds by Engineered Plant Polyketide Synthases
  • Morita, H.^a,b, Mori, T.^a,b, Yamashita, M.^a, Wakimoto, T.^a,b, Abe, I.^a,b
    (^aGraduate School of Pharmaceutical Sciences, The University of Tokyo, ^bCREST, JST)

17

• 細菌由来のsesquarterpenes（C₃₅テルペン）：ユニークな生合成酵素の同定と新規天然物探索
  • (新潟大院自然科学^a、新潟大農応生化^b、新潟大機器分析センター^c)
    ○佐藤　努^a,b、星野紘子^a、吉田　悟^a、滝沢和央^a、折戸悠梨子^a、高木亮輔^a、丹野瑞樹^a、工藤はなよ^b、
    小野恵梨^a、中島真美^c、星野　力^a,b
• Sesquarterpenes (C₃₅ Terpenes) from Bacteria: Identifications of Unique Biosynthetic Enzymes and Search for Novel Natural Products
  • Sato, T.^a,b, Hoshino, H.^a, Yoshida, S.^a, Takizawa, K.^a, Orito, Y.^a, Takagi, R.^a, Tanno, M.^a, Kudo, H.^b, Ono, E.^a, Nakajima, M.^c, Hoshino, T.^a,b
    (^aGraduate School of Science and Technology, Niigata University, ^bFaculty of Agriculture, Niigata University, ^cCenter for Instrumental Analysis, Niigata University)

9:50-11:05

座長：渡辺賢二 (静岡県大薬)
Chair: Watanabe, K. (Department of Pharmaceutical Sciences, University of Shizuoka)

18

• マクロラクタムポリケチド抗生物質ビセニスタチンの生合成におけるアミノ酸スターター部位の構築機構
  • (東工大院理工)
    ○篠原雄治、小笠原泰志、工藤史貴、江口　正
• The Unique Starter Biosynthesis of Macrolactam Polyketide Antibiotic Vicenistatin
  • Shinohara, Y., Ogasawara, Y., Kudo, F., Eguchi, T.
    (Graduate School of Science and Engineering, Tokyo Institute of Technology)

19

• 化合物アレイ型プラットフォームを用いた cytochrome P450 の基質スクリーニング法の開発
  • (東北大院薬^a、理研基幹研ケミカルバイオロジー^b)
    ○叶　直樹^a、高山　浩^a、高橋俊二^b、守谷　崇^a、川又綾乃^a、長田裕之^b、岩渕好治^a
• Development of Chemical Array Platform for Identifying Cytochrome P450 Substrates
  • Kanoh, N.^a, Takayama, H.^a, Takahashi, S.^b, Moriya, T.^a, Kawamata, A.^a, Osada, H.^b, Iwabuchi, Y.^a
    (^aGraduate School of Pharmaceutical Sciences, Tohoku University, ^bChemical Biology Department, RIKEN Advanced Science Institute)

20

• 糸状菌Phomopsis amygdaliが生産するフシコクシン生合成マシナリーの全容解明
  • (北大院工^a、福井県大生物資源^b、阪大産研^c、山形大農^d)
    ○野池基義^a、小野裕介^a、荒木祐治^a、谷尾　亮^a、濱野吉十^b、樋口雄介^c、豊増知伸^d、佐々武史^d、
    加藤修雄^c、大利　徹^a
• Analysis of Biosynthetic Machinery of Fusicoccin Produced by Phomopsis amygdali
  • Noike, M.^a, Ono, Y.^a, Araki, Y.^a, Tanio, R.^a, Hamano, Y.^b, Higuchi, Y.^c, Toyomasu, T.^d, Sassa, T.^d, Kato, N.^c, Dairi, T.^a
    (^aGraduate School of Engineering, Hokkaido University, ^bDepartment of Bioscience, Fukui Prefectural University, ^cInstitute of Scientific and Industrial Research, Osaka University, ^dDepartment of Bioresource Engineering, Yamagata University)

11:10-12:10

ショートプレゼンテーション
Short Presentation
座長：荒井雅吉 (阪大院薬)
Chair: Arai, M. (Graduate School of Pharmaceutical Sciences, Osaka University)

午後

12:10-14:50

ポスター示説
Poster Presentation

14:50-15:00

第54回討論会　案内
渡邉秀典 (東大院農生科)
Watanabe, H. (Graduate School of Agricultural and Life Sciences, The University of Tokyo)

15:00-15:50

座長：千田 憲孝 (慶大理工)
Chair: Chida, N. (Department of Applied Chemistry, Keio University)

21

• ゲルセモキソニンの全合成
  • (東大院薬)
    ○下川　淳、原田尭明、横島　聡、福山　透
• Total Synthesis of Gelsemoxonine
  • Shimokawa, J., Harada, T., Yokoshima, S., Fukuyama, T.
    (Graduate School of Pharmaceutical Sciences, The University of Tokyo)

22

• Decarbamoyl-α-saxitoxinolの全合成
  • (名大院生命農)
    ○澤山裕介、西川俊夫
• Total Synthesis of Decarbamoyl-α-saxitoxinol
  • Sawayama, Y., Nishikawa, T.
    (Graduate School of Bioagricultural Sciences, Nagoya University)

15:50-16:40

座長：徳山英利 (東北大院薬)
Chair: Tokuyama, H. (Graduate School of Pharmaceutical Sciences, Tohoku University)

23

• 連続的シグマトロピー転位の開発とカイノイド類全合成への応用
  • (慶大理工)
    ○北元克典、三瓶真菜、中山泰彰、市來政人、佐藤隆章、千田憲孝
• The Development of Sequential Sigmatropic Rearrangement and Application to the Total Synthesis of Kainoids
  • Kitamoto, K., Sampei, M., Nakayama, Y., Ichiki, M., Sato, T., Chida, N.
    (Department of Applied Chemistry, Keio University)

24

• (+)-Ophiobolin A の不斉全合成
  • (早大院理工)
    ○綱　和宏、野口直義、中田雅久
• The First Enantioselective Total Synthesis of (+)-Ophiobolin A
  • Tsuna, K., Noguchi, N., Nakada, M.
    (Department of Chemistry and Biochemistry, Waseda University)

16:40-17:55

座長：林雄二郎 (東理大工)
Chair: Hayashi, Y. (Department of Engineering, Tokyo University of Science)

25

• エーテル環の立体制御を軸とした生物活性天然物の合成
  • (東大院農生科)
    ○小倉由資、若森晋之介、岡田笑子、石神　健、渡邉秀典
• Syntheses of Bioactive Natural Products Controlling the Stereochemistry of Ether Ring
  • Ogura, Y., Wakamori, S., Okada, S., Ishigami, K., Watanabe, H.
    (Graduate School of Agricultural and Life Sciences, The University of Tokyo)

26

• β-ペンタガロイルグルコース誘導体のヘキサヒドロキシジフェノイル架橋
  • (関西学院大理工)
    ○芦辺成矢、藤本翔平、上野友理、広兼　司、久米裕二、山田英俊
• Hexahydroxydiphenoyl-bridge Formation of a β-Pentagalloylglucose Derivative
  • Ashibe, S., Fujimoto, S., Ueno, Y., Hirokane, T., Kume, Y., Yamada, H.
    (School of Science and Technology, Kwansei Gakuin University)

27

• Penostatin B の全合成
  • (徳島大院薬)
    ○横江弘雅、藤岡孝佑、吉田昌裕、宍戸宏造
• Total Synthesis of Penostatin B
  • Yokoe, H., Fujioka, K., Yoshida, M., Shishido, K.
    (Graduate School of Pharmaceutical Sciences, The University of Tokushima)

第3日　9月29日(木)

午前

9:00-9:50

座長：好光健彦 (阪大院薬)
Chair: Yoshimitsu, T. (Graduate School of Pharmaceutical Sciences, Osaka University)

28

• HIVインテグラーゼ阻害物質OteromycinおよびCYP3A4阻害物質Diaporthichalasinの全合成
  • (東京理大薬^a、東京理大戦略物理製剤研究セ^b)
    ○塩野崎宣裕^a、田中　亮^a、岩村直輝^a、内呂拓実^a,b
• Total Synthesis of HIV-integrase Inhibitor Oteromycin and CYP3A4 Inhibitor Diaporthichalasin
  • Shionozaki, N.^a, Tanaka, R.^a, Iwamura, N.^a, Uchiro, H.^a,b
    (^aFaculty of Pharmaceutical Sciences, Tokyo University of Science, ^bCenter for Drug Delivery Research, Tokyo University of Science)

29

• リチウムアミドの不斉共役付加–アルキル化–環化連続反応を鍵とする(–)-Kopsinineの形式全合成
  • (京大院薬^a、同志社女子大薬^b)
    ○原田慎吾^a、坂井健男^a、山田健一^a、山本康友^b、富岡　清^b
• Formal Total Synthesis of (-)-Kopsinine by Asymmetric Conjugate Amination-Alkylation-Annulation Process
  • Harada, S.^a, Sakai, T.^a, Yamada, K.^a, Yamamoto, Y.^b, Tomioka, K.^b
    (^aGraduate School of Pharmaceutical Sciences, Kyoto University, ^bFaculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts)

9:50-10:40

座長：長澤 和夫 (東農工大院工)
Chair: Nagasawa, K. (Department of Technology, Tokyo University of Agriculture and Technology)

30

• C-Hアミノ化を基盤とするカイトセファリンの全合成研究
  • (長崎大院医歯薬)
    ○高橋圭介、山口大介、Lu, Shenlei、石原　淳、畑山　範
• Synthetic Study on Kaitocephalin Based on C-H Amination Strategy
  • Takahashi, K., Yamaguchi, D., Lu, S., Ishihara, J., Hatakeyama, S.
    (Graduate School of Biomedical Sciences, Nagasaki University)

31

• マンノペプチマイシンアグリコンの全合成
  • (東工大院理工^a、東北大院薬^b)
    ○布施新一郎^a、肥沼宏次^a、金原　篤^a、土井隆行^b、高橋孝志^a
• Total Synthesis of Mannopeptimycin Aglycon
  • Fuse, S.^a, Koinuma, H.^a, Kinbara, A.^a, Doi, T.^b, Takahashi, T.^a
    (^aApplied Chemistry, Tokyo Institute of Technology, ^bGraduate School of Pharmaceutical Sciences, Tohoku University)

10:40-11:55

座長：菅　敏幸 (静岡県大薬)
Chair: Kan, T. (School of Pharmaceutical Sciences, University of Shizuoka)

32

• ポリセオナミドミミックの設計・全合成・イオンチャネル機能
  • (東大院薬)
    ○伊藤寛晃、松岡　茂、井上将行
• Design, Total Synthesis and Functional Analysis of Polytheonamide Mimic, an Artificial Ion Channel Peptide
  • Itoh, H., Matsuoka, S., Inoue, M.
    (Graduate School of Pharmaceutical Sciences, The University of Tokyo)

33

• 多環式アルカロイド群の分岐型迅速合成プロセス：生合成を模倣した構造多様化戦略
  • (北大院理)
    ○溝口玄樹、大栗博毅、及川英秋
• Divergent Synthesis of Multicyclic Alkaloids Inspired by Biosynthetic Strategy
  • Mizoguchi, H., Oguri, H., Oikawa, H.
    (Graduate School of Science, Hokkaido University)

34

• 海洋細菌が産生するセリンプロテアーゼ阻害剤マリノスタチンの構造と機能
  • (ペプチド研^a、生物研・蛋白質機能ユニット^b、阪大院薬^c、阪大微研^d、阪大院理^e、大阪薬大^f)
    ○泰地美沙子^a、山崎俊正^b、河原一樹^c、元岡大祐^c、中村昇太^d、豊島　正^a,e、大久保忠恭^c、小林祐次^f、
    西内祐二^a,e
• Structure-Function Study of Marinostatin, a Natural Ester-Linked Serine Protease Inhibitor
  • Taichi, M.^a, Yamazaki, T.^b, Kawahara, K.^c, Motooka, D.^c, Nakamura, S.^d, Teshima, T.^a,e, Ohkubo, T.^c, Kobayashi, Y.^f, Nishiuchi, Y.^a,e
    (^aResearch Division, Peptide Institute, Inc., ^bProtein Research Unit, National Institute of Agrobiological Science, ^cGraduate School of Pharmaceutical Sciences, Osaka University, ^dResearch Institute for Microbial Diseases, Osaka University, ^eGraduate School of Science, Osaka University, ^fSchool of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences)

11:55-13:00

休憩

午後

13:00-13:50

座長：門田　功 (岡山大院自然科学)
Chair: Kadota, I. (Graduate School of Natural Science and Technology, Okayama University)

35

• カイニン酸誘導体MFPAの合成
  • (静岡県大薬^a、東大院薬^b、京大化研^c、サントリー生科財団^d、北大院水^e)
    ○浅川倫宏^a、大内仁志^a、鈴木寛人^a、磯部洋一郎^a、東　匠^a、岡崎優子^a、脇本敏幸^b、古田　巧^c、島本啓子^d、酒井隆一^e、濱島義隆^a、菅　敏幸^a
• Stereocontrolled Synthesis of (+)-Methoxyphenylkainic acid
  • Asakawa, T.^a, Ohuchi, H.^a, Suzuki, H.^a, Isobe, Y.^a, Higashi, T.^a, Okazaki, Y.^a, Wakimoto, T.^b, Furuta, T.^c, Shimamoto, K.^d, Sakai, R.^e, Hamashima, Y.^a, Kan, T.^a
    (^aSchool of Pharmaceutical Sciences, University of Shizuoka, ^bGraduate school of Pharmaceutical Sciences, The University of Tokyo, ^cInstitute for Chemical Research, Kyoto University, ^dBioorganic Research Institute, Suntory Foundation for Life Sciences, ^eFaculty of Fisheries Sciences, Hokkaido University)

36

• ペクテノトキシン2の全合成
  • (北大院理^a、青森保健大^b)
    藤原憲秀^a、○鈴木悠記^a、古関　直^a、菊地悠太^a、村田俊一^a、安藝祐一^a、山本冬樹^a、河村真理子^a、
    岡野　梓^a、村井章夫^a、河合英敏^a、鈴木孝紀^a、乗鞍敏夫^b、松江　一^b
• Total Synthesis of Pectenotoxin-2
  • Fujiwara, K.^a, Suzuki, Y.^a, Koseki, N.^a, Kikuchi, Y.^a, Murata, S.^a, Aki, Y.^a, Yamamoto, F.^a, Kawamura, M.^a, Okano, A.^a, Murai, A.^a, Kawai, H.^a, Suzuki, T.^a, Norikura, T.^b, Matsue, H.^b
    (^aDepartment of Chemistry, Faculty of Science, Hokkaido University, ^bDepartment of Nutrition, Faculty of Health Science, Aomori University of Health and Welfare)

13:50-14:40

座長：川端猛夫 (京大化研)
Chair: Kawabata, T. (Institute for Chemical Research, Kyoto University)

37

• 抗腫瘍性抗生物質C-1027クロモフォアの全合成研究
  • (東北大院理)
    ○佐藤　格、田村幸男、平井啓一朗、平川文弥、平間正博
• Synthetic Study of Antitumor Antibiotic C-1027 Chiromophore
  • Sato, I., Tamura, Y., Hirai, K., Hirakawa, F., HIrama, M.
    (Department of Chemistry, Faculty of Science, Tohoku University)

38

• CF₂及びCH₂-シアロシド結合を有する代謝安定型ガングリオシドGM3の合成と活性
  • (理研基幹研^a、ERATO-JST^b、東北薬大^c)
    ○平井　剛^a、加藤麻理依^a、渡邉　亨^a、西澤絵里^a、大沼可奈^a、土屋綾子^a、越野広雪^a、宮城妙子^c、
    袖岡幹子^a,b
• Synthesis and Biological Activity of Ganglioside GM3 Analogues with CF₂- and CH₂-Sialoside Linkage
  • Hirai, G.^a, Kato, M.^a, Watanabe, T.^a, Nishizawa, E.^a, Oonuma, K.^a, Tsuchiya, A.^a, Koshino, H.^a, Miyagi, T.^c, Sodeoka, M.^a,b
    (^aAdvanced Science Institute, RIKEN, ^bSodeoka Live Cell Chemistry Project, ERATO-JST, ^cInstitute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University)

14:40-15:30

座長：土井隆行 (東北大院薬)
Chair: Doi, T. (Graduate School of Pharmaceutical Sciences, Tohoku University)

39

• 有機触媒による糖類の位置選択的アシル化：配糖体天然物の位置選択的全合成並びに官能基化
  • (京大化研)
    ○上田善弘、三代憲司、村松　渉、吉田圭佑、古田　巧、川端猛夫
• Organocatalytic Regioselective Protocol for Total Synthesis and Functionalization of Natural Glycosides
  • Ueda, Y., Mishiro, K., Muramatsu, W., Yoshida, K., Furuta, T., Kawabata, T.
    (Institute for Chemical Research, Kyoto University)

40

• X線結晶構造解析に裏付けされた糖タンパク質の精密有機化学合成
  • (阪大院理^a、Chicago 大 ^b、UCLA^c)
    ○岡本　亮^a、Mandal, Kalyaneswar^b、Sawaya, Michael^c、Yeates, Todd^c、Kent, Stephen^b、梶原康宏^a
• The Precise Chemical Glycoprotein Synthesis Assigned by a Unique X-ray Crystallography
  • Okamoto, R.^a, Mandal, K.^b, Sawaya, M.^c, Yeates, T.^c, Kent, S.^b, Kajihara, Y.^a
    (^aGraduate School of Science, Osaka University, ^bDepartment of Chemistry, The University of Chicago, ^cDepartment of Chemistry and Biochemistry, University of California Los Angeles)

15:30-16:20

座長：西川俊夫 (名大院生命農)
Chair: Nishikawa, T. (Graduate School of Bioagricultural Sciences, Nagoya University)

41

• タンパク質間相互作用阻害活性を有するThielocin B1の全合成と相互作用解析
  • (東北大院薬^a、JBIC^b、AIST 生命情報工学研究センター^c、AIST バイオメディシナル情報研究センター^d、NINS^e)
    ○吉田将人^a、大澤宏祐^a、高木基樹^b、広川貴次^c、植草義徳^e、加藤晃一^e、新家一男^d、夏目　徹^d、土井隆行^a
• Total Synthesis of Thielocin B1
  • Yoshida, M.^a, Ohsawa, K.^a, Takagi, M.^b, Hirokawa, T.^c, Uekusa, Y.^e, Kato, K.^e, Shin-ya, K.^d, Natsume, T.^d, Doi, T.^a
    (^aGraduate School of Pharmaceutical Sciences, Tohoku University, ^bBiomedicinal Information Research Center, Japan Biological Infomatics Consortium, ^cComputational Biology Research Center, National Institute of Advanced Industrial Science and Technology, ^dBiomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology, ^eOkazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences)

42

• エポキシドの加水分解反応を引き金とする仮想生合成様オキサ環化反応に基づくオキササイクリックテルペノイドの全合成
  • (阪市大院理)
    ○児玉　猛、青木慎悟、松尾知樹、竹内絵里子、星野晃大、舘　祥光、森本善樹
• Total Synthesis of Oxacyclic Terpenoids Based on the Hypothetical Biomimetic Oxacyclization Triggered by Hydrolysis of an Epoxide
  • Kodama, T., Aoki, S., Matsuo, T., Takeuchi, E., Hoshino, A., Tachi, Y., Morimoto, Y.
    (Graduate School of Science, Osaka City University)

16:20-17:35

座長：大野浩章 (京大院薬)
Chair: Ohno, H. (Graduate School of Pharmaceutical Sciences, Kyoto University)

43

• Dictyodendrin A-Eの全合成
  • (東北大院薬^a、東大院薬^b)
    ○岡野健太郎^a,b、藤原栄人^a、野地寿治^a、福山　透^b、徳山英利^a,b
• Total Synthesis of Dictyodendrins A-E
  • Okano, K.^a,b, Fujiwara, H.^a, Noji, T.^a, Fukuyama, T.^b, Tokuyama, H.^a,b
    (^aGraduate School of Pharmaceutical Sciences, Tohoku University, ^bGraduate School of Pharmaceutical Sciences, The University of Tokyo)

44

• 免疫調節作用制御を目指した寄生性細菌由来リポ多糖部分構造の集積的合成法の開発と機能解析
  • (阪大院理)
    ○下山敦史、佐伯昭典、来山直弘、笠松千郁、藤本ゆかり、深瀬浩一
• Immunoregulatory Parasitic Bacterial Lipopolysaccharide Partial Structures; Integrated Synthesis and Immune Functional Analysis
  • Shimoyama, A., Saeki, A., Kitayama, N., Kasamatsu, C., Fujimoto, Y., Fukase, K.
    (Graduate School of Science, Osaka University)

45

• C-Hアリール化反応を駆使したdragmacidin Dの全合成
  • (名大院理)
    ○山口潤一郎、マンダルデバシス、山口敦史、伊丹健一郎
• Synthesis of Dragmacidin D via Direct C-H Bond Arylation
  • Yamaguchi, J., Mandal, D., Yamaguchi, A., Itami, K.
    (Graduate School of Science, Nagoya University)